CD36 gene polymorphism is associated with Alzheimer's disease.
Identifieur interne : 001069 ( Main/Exploration ); précédent : 001068; suivant : 001070CD36 gene polymorphism is associated with Alzheimer's disease.
Auteurs : Omar Šer [République tchèque] ; Jana Janoutová ; Laura Ewerlingová ; Alice Hálová ; Jan Lochman ; Vladimír Janout ; Naim A. Khan [France] ; Vladimir J. Balcar [Australie]Source :
- Biochimie [ 1638-6183 ] ; 2017.
Descripteurs français
- KwdFr :
- Antigènes CD36 (génétique), Cholestérol (métabolisme), Femelle, Génotype, Humains, Maladie d'Alzheimer (génétique), Maladie d'Alzheimer (métabolisme), Mâle, Polymorphisme de nucléotide simple (génétique), Polymorphisme génétique (génétique), Prédisposition génétique à une maladie (génétique), Stress oxydatif, Sujet âgé.
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Antigens, CD36.
- genetics : Alzheimer Disease, Genetic Predisposition to Disease, Polymorphism, Genetic, Polymorphism, Single Nucleotide.
- metabolism : Alzheimer Disease, Cholesterol.
- Aged, Female, Genotype, Humans, Male, Oxidative Stress.
Abstract
CD36 gene encodes a membrane glycoprotein (type B scavenger receptor) present on the surface of many types of cells and having multiple cellular functions ranging from angiogenesis to gustatory perception of fatty acids. Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.
DOI: 10.1016/j.biochi.2017.01.009
PubMed: 28111291
Affiliations:
- Australie, France, République tchèque
- Bourgogne, Bourgogne-Franche-Comté, Nouvelle-Galles du Sud
- Sydney
- Université de Sydney
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Le document en format XML
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Using a case control genetic association approach we have analyzed selected single nucleotide polymorphisms (SNP's) in a total of 859 patients with Alzheimer's disease (AD) and controls and have identified the allele A in rs3211892 polymorphism of CD36 gene as significantly increasing the risk of AD. Additionally we have investigated, in the same sample of control subjects and patients, SNP's in ApoE gene and confirmed that the previously identified AD-associated SNP's indeed increased the risk and decreased the age of onset of AD as reported by others earlier. Based on the current knowledge of CD36 biochemistry we propose that the AD risk-imparting variants of CD36 alter cholesterol homeostasis, oxidation stress or induce pathological inflammatory cascades. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>République tchèque</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><noCountry><name sortKey="Ewerlingova, Laura" sort="Ewerlingova, Laura" uniqKey="Ewerlingova L" first="Laura" last="Ewerlingová">Laura Ewerlingová</name><name sortKey="Halova, Alice" sort="Halova, Alice" uniqKey="Halova A" first="Alice" last="Hálová">Alice Hálová</name><name sortKey="Janout, Vladimir" sort="Janout, Vladimir" uniqKey="Janout V" first="Vladimír" last="Janout">Vladimír Janout</name><name sortKey="Janoutova, Jana" sort="Janoutova, Jana" uniqKey="Janoutova J" first="Jana" last="Janoutová">Jana Janoutová</name><name sortKey="Lochman, Jan" sort="Lochman, Jan" uniqKey="Lochman J" first="Jan" last="Lochman">Jan Lochman</name></noCountry><country name="République tchèque"><noRegion><name sortKey="Ser, Omar" sort="Ser, Omar" uniqKey="Ser O" first="Omar" last="Šer">Omar Šer</name></noRegion></country><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Khan, Naim A" sort="Khan, Naim A" uniqKey="Khan N" first="Naim A" last="Khan">Naim A. Khan</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Balcar, Vladimir J" sort="Balcar, Vladimir J" uniqKey="Balcar V" first="Vladimir J" last="Balcar">Vladimir J. Balcar</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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